WGCNA revisited: Module indetification

Abstract

Abstract WGCNA is a very popular R language software package used in biomedical field. It is mainly designed to deal with gene microarray samples to find clusters (modules), which include highly correlated genes, in biomedical studies. Theoretically, it results in the hierarchical modules, which are different from the results based on the edge density inside module and outside modules. In this study, we address this difference and indicate that caution should be exercised when using these two methods to interpret the implication of studies.