Development of intelligent redox-responsive biopolymer-based antibacterial coating for controlled drug release

Abstract

Abstract Most antibacterial coatings face challenges related to uncontrolled and rapid release of antimicrobial agents. Consequently, developing intelligent antibacterial coatings featuring controlled and on-demand drug release has become imperative. In this study, we prepared a redox-responsive biopolymer, γ-PGA-PDA-DA, by modifying γ-polyglutamic acid (γ-PGA) with dopamine (DA) and pyridine dithioethylamine hydrochloride (PDA). The γ-PGA-PDA-DA biopolymer was assembled with the antibacterial agent ofloxacin (OFL) to prepare drug-loaded colloidal particles. Colloidal particle size and morphology were characterized through TEM, zeta potential analysis, and nanoparticle size analysis. Subsequently, an oxidation-reduction responsive drug delivery antibacterial coating was formed on the surface of 316 L stainless steel through electrophoretic deposition (EPD). The responsive drug release and antimicrobial properties of the coating were assessed via drug release experiments and antibacterial zone tests. The results demonstrate the effective bactericidal effects and highlight its intelligent antibacterial coating functionality.