Author:
Chikhirzhina E V,Starkova T Yu,Polyanichko A M
Abstract
Abstract
Using UV absorption spectroscopy and circular dichroism, we studied the interaction of DNA-cisplatin complexes with nonhistone chromosomal proteins HMGB1 and HMGB2. It was shown that the presence of platinum ions affected the ability of HMGB2 to form large supramolecular complexes with DNA. The role of C-terminal domain of the HMGB1/2 proteins is discussed.
Subject
General Physics and Astronomy