Numerical calculation for effectively simulating the electric field in electroporated tissue

Abstract

Abstract At present, cell membrane perforation technology has been widely used in biology and clinical medicine. Therefore, it is important to master the change pattern of perforated cell membrane potential to further improve the research and application of cell perforation technology. Among them, numerical simulation is an important tool to noninvasively study the effects of tissue properties, electrode arrangement and pulse transmission scheme during electroporation. In this paper, an improved Newton’s method is used to predict pulse voltages and to verify the fit of the method used in this paper for different tissue parameters in a numerical computational model developed specifically for electroporation. The purpose is to improve the reference for researchers to provide faster and more accurate iterative algorithms when studying the electroporation mechanism. The comparative analysis of simulation results between this paper and COMSOL software shows that the method can improve the accuracy of predicting the electric field distribution, reduce the number of iterations, and the effect is well fitted under different tissue parameters. We believe that this knowledge will contribute to a better understanding of in vivo electroporation kinetics and improve electroporation treatment planning techniques.