Synthesis, Characterization and biological Study of some new derivatives from Pregnenolone via McMurry reaction

Abstract

Abstract A series of some new Pregnenolone derivatives have been synthesized by McMurry reaction which include using of (Low-Valent) titanium from (TiCl4) with (Zn-dust) as catalyst and (THF) as a solvent to convert the (ketonic carbonyl group) of Pregnenolone with a new aldehyde or ketone compound to a new aliphatic double bond connected each other. All the new synthesized derivatives were monitored by (TLC) and assigned by elemental analysis, melting points, FT-IR and (1H NMR, 13C NMR and 2D-NMR) spectroscopy. The anti-bacterial and anti-fungi activity of these derivatives were also determined.