Studying the Effect of Some Thiadiazole Derivatives on the Activity of LDH Enzyme-Reference-Cited by-同舟云学术

Studying the Effect of Some Thiadiazole Derivatives on the Activity of LDH Enzyme

Published:2019-09-01 Issue:5 Volume:1294 Page:052061
ISSN:1742-6588
Container-title:Journal of Physics: Conference Series
language:
Short-container-title:J. Phys.: Conf. Ser.

Author:

Hazim Abeer,Sabah Rulla,AL-dulaimi Muayad

Abstract

Abstract This work involved studying the effect of some thiadiazole derivatives on the activity of lactate dehydrogenase enzyme (LDH) in the serum of normal control and thalassemia patients. The results showed that all the compounds used had inhibitory effect on LDH enzyme activity, the inhibition percent was between (7.87%-55.22%) depending on compound structure and its concentration. Studying kinetic properties showed that these compounds behave as non-competitive inhibitors.

Publisher

IOP Publishing

Subject

General Physics and Astronomy

Link

https://iopscience.iop.org/article/10.1088/1742-6596/1294/5/052061/pdf

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