New immunological markers for the identification of lung cancer risk groups among workers in hazardous industries in Kuzbass region

Author:

Ustinov V A,Nekrash M S,Studennikov A E,Glushkov A N

Abstract

Abstract Polycyclic aromatic hydrocarbons are widely known as risk factor in relation to lung cancer development. In this connection, we suggested to use idiotypic and anti-idiotypic antibodies IgG and IgA classes against polycyclic aromatic hydrocarbons in human blood serum as new biomarkers for lung cancer risk. The blood serums of 202 healthy men and 275 men with lung cancer were analyzed by ELISA based on idiotypic and anti-idiotypic antibodies IgG and IgA classes against polycyclic aromatic hydrocarbons. Obtained data were analyzed. It was suggested to use ratio of idiotypic and anti-idiotypic antibodies rather than distinguish level each of them separately. The neural networks for idiotypic and anti-idiotypic antibodies of IgG class (AUC = 0.95), idiotypic and anti-idiotypic antibodies of IgA class (AUC = 0.86), and idiotypic and anti-idiotypic antibodies of IgA and IgG classes (AUC = 0.93) were built as models for lung cancer predictions. Finally, the ELISA data of 52 Kuzbass region coal miners were identified as a group of lung cancer risk using obtained models. So, suggested markers antibodies in human blood serum were not only identified lung cancer patients also elicited group of lung cancer risk among healthy people.

Publisher

IOP Publishing

Subject

General Physics and Astronomy

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3