FAS and FASL polymorphisms and susceptibility to hepatitis B virus infection in Javanese individuals

Abstract

Abstract Hepatitis B virus infection is still a major global health problem. The polymorphisms in FAS and FASL genes may involve with susceptibility to hepatitis B virus infection for Javanese. To investigate the association of FAS and FASL polymorphisms with the susceptibility to hepatitis B virus infection in Javanese individuals, blood samples with hepatitis B virus infection was subjected for polymerase chain reaction-restriction fragment length polymorphism to genotype the FAS-670 A/G and FASL -124A/G polymorphism status, respectively. The frequencies of G/G genotype and G allele of FAS gene in the hepatitis B virus-infected blood sample were higher than that of the healthy sample (OR 3.5, 95%CI: 1.658 - 7.390, p = 0.001 and OR 2.3, 95%CI: 1.352 - 3.779, p = 0.002, respectively). It is proposed that the hepatitis B virus infection outcome in Japanese individuals might be influenced by FAS-670 A/G polymorphism through alteration in apoptosis of hepatocytes.