Evaluation on Machine Learning Algorithms for Classification of Autism Spectrum Disorder (ASD)

Abstract

Abstract Autism Spectrum Disorder (ASD) was characterized by delay in social interactions development, repetitive behaviors and narrow interest, which usually diagnosed with standard diagnostic tools such as Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADIR-R). Previous work has implemented machine-learning methods for the classification of ASD, however they used different types of dataset such as brain images for MRI and EEG, risk genes in genetic profiles and behavior evaluation based on ADOS and ADI-R. Here a trial on using Autism Spectrum Questions (AQ) to build models that have higher potential to classify ASD was developed. In this research, Chi-square and Least Absolute Shrinkage and Selection Operator (LASSO) have been selected as feature selection methods to select the most important features for 3 supervised machine learning algorithms, which are Random Forest, Logistic Regression and K-Nearest Neighbors with K-fold cross validation. The performance was evaluated in which results Logistic Regression scored the highest accuracy with 97.541% using model with 13 selected features based on Chi-square selection method.