Study on Biocompatibility of Chitosan/Hydroxyapatite Doped Silicon Composite as Material for Alveolar Socket Preservation

Abstract

Abstract As the Alveolar Socket Preservation (ASP) was developed as a procedure for placement of bone graft on sockets where the tooth was removed, a new composite of Chitosan/Hydroxyapatite doped Silicon (Chi/HAp-Si) was synthesized. Si will be added to HAp in amount 7 wt% by a solid-state method. As a comparison, the HAp-Si later will be mixed with chitosan with variations of 0, 5, 10, and 15 wt%, with the aim of enhancing antibacterial ability against S. aureus bacteria. The synthesized samples were characterized using XRD and SEM. Antibacterial activities of the Chi/HAp-Si composite were evaluated against S. aureus bacteria. The addition of chitosan did not have much effect on the biocompatibility of HAp-Si, especially in S. aureus bacteria. However, the addition of chitosan to the 10 wt% composition has the highest antibacterial properties.