Antioxidant Potential of the Shell of Razor Clams (Solen spp) in Antidiabetic Mellitus Type II Therapy

Abstract

Abstract Razor clams (Solen spp) are one type of bivalves found in Madura waters and suggested to have antioxidant bioactive compounds. This research was conducted to determine the chemical compounds and antioxidant activity as well as testing blood sugar levels on mice that are conditioned to suffer from diabetes mellitus. The extraction method used is stratified by using three solvents which have different polarity. The test being done was phytochemistry tests to determine the bioactive compounds contained in the shell of razor clams, DPPH method to determine antioxidant activity, and blood sugar test in mice. The crude extracts of the shell of razor clams is contained alkaloid and saponins The highest antioxidant activity (IC50) was found from the shell of razor clams extracted eith ethanol was 489.56 ppm. The results of the blood sugar test showed that the addition/consumption of antioxidant extract of razor clams of 0.0063g/20g body weight (BW) was able to reduce blood sugar levels of mices with diabetes mellitus type 2.