The Dynamics of Ureter Changes After Medial and Distal Unilateral Ureteral Obstruction in Rat

Abstract

Abstract Unilateral ureteral obstruction is an abnormality that often occurs in the urinary tract. Obstruction can be placed proximal, medial or distal ureter. The physiological response that occurs depends on the severity, duration, location and type of obstruction. The aim of this study was to look at the macroscopic and histopathological changes of the ureter also Hydronephrosi Hydroureter Index after medial and distal unilateral ureteral obstruction. Thirty-six white rats were divided into 3 groups and each group consist of 12 individuals. Group I as a control got a laparotomy without ureter ligation. Group II laparotomy with medial right ureteral ligation and group III laparotomy with distal right ureter ligation. Three rats in each group were randomly collected at weeks 1, 2, 3 and 4 after treatment. The kidneys and ureters were removed from the abdominal cavity to measure the diameter of the ureter and weigh. After the accumulated liquid was taken, the weighing was done again. An ureter sample was taken for histopathological preparations. The results of the macroscopic and histopathological examination of the ureter were discussed qualitatively. Measurement of the diameter and thickness of the ureteric wall was analyzed using statistical analysis of factorial pattern variations 3x4. The accumulation of fluid in the ureter causing changes in the shape, color, size and structure of the ipsilateral ureter in both ligation groups. Histopathological observations showed depletion, alteration and damage to the structure of the ipsilateral ureteric wall structure. Unilateral ureteral obstruction affected ureter diameter increase, thinning of the ureteral wall and ipsilateral IHH (P <0.05). The presence of unilateral ureteral obstruction had no impact on the contralateral ureter (P> 0.05).