Acute effect of tomato extract (Lycopersicum esculentum) on rat’s (Rattus norvegicus) behavior and body weight

Abstract

Abstract Tomato is one of the natural beneficial fruits. It contains lycopene, one of the effective carotenoids, also tocopherol, Vitamin C, Vitamin A and many more nutrition. Mostly, people consumes tomato uncontrolled. It commonly consumed in large quantities and for long periods of time. Based on that cases, it needs to be considered because the consumption of excess antioxidants can trigger a back reaction and increase pro-oxidant compounds. Therefore, this research was to determine the safety level of pure tomato consumption. This research is an experimental research with high tomato dose as treatments. Five group i.e. control (K) 0 mg/ individual tomato extract; K1, 16 mg/ individual tomato extract; K2, 160 mg/ individual tomato extract; K3, 1600 mg/ individual tomato extract; and K4 16.000 mg/ individual tomato extract. Natural tomato extract doses that used for supplementation did not have acute toxicity. The observed behavior in rats did not show any significant difference between treatment and control group. This is probably the dose used in the study is still in tolerant dose for rats metabolism. So, it can be concluded that there is no acute effect on consumption of lycopene extract from tomato.