Protective Effects of Collagen Peptide on Periodontal Ligament Fibroblasts

Abstract

Abstract To study the protective effect of collagen peptide on human periodontal ligament fibroblasts (hPDLFs) induced by lipopolysaccharide and its possible mechanism. Lipopoly-saccharide was used as a pathogenic factor to stimulate hPDLFs. Then, interleukin-8 and tumor necrosis factor-α in the supernatant were quantified, and Toll-like receptor 4 expression and the activation of nuclear factor-κB pathway were also studied. The results showed that collagen peptide above 100 mg/L could effectively reduce the toxicity of lipopolysaccharide, and significantly reduce interleukin-8 and tumor necrosis factor-α produced by lipopolysaccharide. Suggesting that collagen peptide can provide effecitve and safe solution to oral cavity repair.