Analysis of the effect of doped metal ions in the tricalcium phosphate bioceramic

Abstract

Abstract Calcium phosphate bioceramics such as hydroxyapatite (HA) and tricalcium phosphate (TCP) were successfully used in medical fields such as dentistry, orthopedics, and facial surgery due to their resorption and bioactivity characteristics. This work aims to obtain an osteoinductive ceramic matrix doped with metal ions. First, TCP doped with 10 mol.% of MgO was selected for the initial matrix due to the increased of HA content, microstructure densification (90%), and mechanical strength (27 MPa). Second, the addition of others metal ions (Zn, Mn, and Fe), at most 5 mol.%, to this initial matrix was evaluated by means of statistical analysis applying design of experiments (DOE). The presence of metal ions was studied by XRD and SEM-EDX analysis. The trace plots and equations were obtained for apparent and relative densities, apparent porosity, and diametral compression resistance, all for a 95% confidence interval and maximum error of p < 0,05. The results show a strong dependency between the addition of these metal ions and all studied properties.