Role of toll like receptor-9 (1237 T/C) gene polymorphism in patients with type 2 diabetes and diabetic foot ulcer

Abstract

Abstract This study aimed to evaluate whether (1237 T/C) polymorphism is related with diabetic foot ulcer in type-2 diabetes mellitus of Iraqi patients in Najaf city. Diabetic foot ulcer (DFU) is one of the most prevalent and serious diabetic complications. DFU accounts for about 15% of the diabetic population. It is commonly associated with the increased diabetic morbidities and mortalities. The type 2 diabetes is recognized by aberrations of glucose, lipid and protein metabolism. It is increasingly appreciated that wound healing defect seen in diabetic patients is attributed to the altered protein and lipid metabolism. This study involved (180) subjects, between them, 60 were patients as group one suffering from type 2 diabetes and 60 were patient suffering from type 2 diabetes and foot ulcer as group two. In addition, 60 healthy group three as control subjects. Polymerase chain analysis was used for detection of TLR-9 genotypes followed by restriction analysis. We observed no significance differences in the distribution of the genotypes and alleles of (1237 T/C) polymorphism among the study groups.