In vitro study of the effect of zinc oxide nanoparticles on Streptococcus mutans isolated from human dental caries

Abstract

Abstract Dental caries is a public health concern worldwide for which Streptococcus mutans has been reported Known as the potential etiology of infection. In recent years, nanotechnology has applied to Creation of novel material properties. The research was studying the effects of Nanoparticles of Zinc Oxide on Streptococcus mutans isolate from dental caries. In this research, Different ZnO NPs concentrations were studied as its anti-bacterial effects on Streptococcus mutans was isolated from dental caries cases. 27 Streptococcus mutans isolates were obtained, which is equivalent to 20% of the total number of 135 isolates. This nanomaterial was chosen because it has a high affinity for human cells and does not cause harm compared to other nanoparticles. The nanoparticles are those very fine materials that can be produced so that their dimensions or the dimensions of their grains range from (1-100) nanometers, and because of the small size of the nanomaterials, which made them behave differently from large-sized materials whose size exceeds 100 nanometers, and because of the small size of the particles. Nanoparticles, which gave them electrical and magnetic properties that differ from large particles of the same compounds. The well diffusion method and the MIC experiment were conducted, and the results were good, as in the well diffusion method the efficacy increased with increasing the concentration of ZnO NPs. In the MIC experiment, it was observed that MIC in the sixth tube, meaning that the MIC of ZnO NPs towards Streptococcus mutans equals 0. 312 mg / ml.