A Novel Coated Wire Electrode And Coated Graphite Electrode for Potentiometric Determination of Amitriptyline Hydrochloride in its pharmaceutical preparations, urine and blood plasma

Abstract

Abstract This paper uses the potentiometric method to evaluate (amitriptyline hydrochloride, AM) by creating selective electrodes for AM drugs with the active ingredient (Ammonium Reinackate, AR) using a plasticizer (Dibutyl phthalate, DBP). The results showed that for (Coated Wire Electrode (CWE)) and Coated Graphite Electrode (CGE) respectively, the Nernstian slope of the prepared Am-AR-DBP electrodes is (57.293, 58.803 mV / decade). With a pH range of (4-7) and a concentration range of 1 ?? 10 ?? Λ(-6)-1 ?? 10 ?? Λ(-1) M for both electrodes, the upper and lower limit of detection for the Am-AR-DBP CGE is 0.2042M, 4.8 ?? 10 ? Λ(-7) M, and the upper and lower limit of detection for the Am-AR-DBP CWE electrode is 0.2051M, 4.91 ?? 10Λ(-7) M, respectively. The response time ranges from 20-83 sec, 14-76 sec for CWE and CGE electrodes respectively. For the CWE electrode, the age of the electrodes is 26 days, and for the CGE electrode, 42 days. The research included calculating the selectivity with the presence of interferers of these electrodes where the K(i, j)Λpot values for all ions were less than 1. In the estimation of the drug Amitriptyline Hydrochloride in the pharmaceutical preparation (Amitriptyline tablets), the manufactured electrodes were used by following the direct process, the standard method of additions, the possible titration method and the homogeneity of the material sample, as well as the drug was estimated in urine and blood plasma with a recovery of not less than 100.57 for urine and 99.46 f for urine.