Detection of Liver Dysfunction using Microfluidics Analysis

Abstract

Abstract The body fluids are an important clinical diagnostic marker, considered by the physicians for diagnosis, monitoring and treating various diseases. Bilirubin, orange-yellow coloured pigment, an end-product of heme metabolism is a biomarker for liver dysfunction primarily jaundice. Similarly, blood pressure is one amongst the main parameters raised in most of the abnormalities including liver dysfunction. Hence, screening of blood pressure and concentration of bilirubin in the blood stream helps to detect the pathological conditions. In COMSOL Multiphysics, fluid flow simulation task is taken into account to analyze the flow of blood, blood pressure, bilirubin and also their range of concentration. In the present work, liver dysfunction can be detected in early stage with the help of physiological behavior of hepatic artery by measuring the flow rate, blood pressure and bilirubin levels in the arteries with the aid of COMSOL Multiphysics simulation software. Also, the impact of obstruction due to the presence of blocks of various sizes in the arteries on the flow rate, bilirubin as well as blood pressure is explored.