Analysis of infrared spectra of blood serum of patients with multiple myeloma

Author:

Chernyshev D A,Mikhailets E S,Telnaya E A,Plotnikova L V,Garifullin A D,Kuvshinov A Y,Voloshin S V,Polyanichko A M

Abstract

Abstract Multiple myeloma (MM) is a serious disease that is difficult to diagnose especially at early stage. Infrared spectroscopy is a promising approach for diagnosing MM. The principal component analysis (PCA) allows us to reduce the dimension of the data and keep only the important variables. In this study, we apply principal components analysis to infrared (IR) spectra of blood serum from healthy donors and multiple myeloma patients. As a result of the analysis by PCA, it was possible to visualize the separation of patient’s and donor’s samples into two clusters. The result indicates that this method is potentially applicable for diagnosis of multiple myeloma.

Publisher

IOP Publishing

Subject

General Physics and Astronomy

Reference10 articles.

1. Multiple Myeloma: Diagnosis and Treatment;Rajkumar;Mayo Clinic Proceedings,2016

2. Multiple Myeloma;Palumbo;New England Journal of Medicine,2011

3. “Nonsecretory” multiple myeloma (a review of literature and own data;Ryzhko;Clinical Oncohematology,2010

4. Comparative analysis of FTIR spectra of serum from multiple myeloma patients and healthy donors;Plotnikova;Vestnik SPbSU. Physics and Chemistry,2017

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