RESISTIVITY OF PROTEIN KINASE-B (AKT), NF-κB TRANSDUCTION OBSTACLES, AND APOPTOSIS INDUCTION (CASPACE -3, -9) AS ANTI-PROLIFERATION AND ANTI-CANCER OF BURKITT’S LYMPHOMA USING FLAVONOID FRACTION OF ETHYL ACETATE FROM ANT NEST (MYRMECODIA PENDANS)

Abstract

Abstract Introduction: Burkitt’s lymphoma (LB) is a tumor with high malignancy and rapid cell growth and originates from B-cell lymphoma. LB is usually found in children in endemic areas with dengue fever and HIV-AIDS with low socioeconomic levels. Objective: This research aims to analyze resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkiit’s lymphoma using flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans). Material and Methods: The study was conducted in a pure laboratory experimental method using burkitt’s lymphoma cancer cell culture. Gradual research begins with the determination, extraction and fractionation of ant nest plants, to test for proliferation barriers. Data analysis using two-way ANOVA followed by Post Hoc LSD test with a significance level of 95%. Pearson correlation test was conducted. Results: Resistivity of protein expression of protein kinase-B (Akt), transcription factor of nuclear factor-kappa B (NF-κB), and apoptosis induction (Caspace -3,-9) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-κB and growth factors that induces the phosphorylation of Akt signal transduction pathway, and apoptosis induction (Caspace -3,-9). Conclusion: Flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans) resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkitt’s lymphoma.