A Simulation Study on the Reentrant Waves in the Pacing Ventricular Tissues

Abstract

Abstract The aim of the study is to investigate the relationship between the reentrant waves and I K1, and probe the effect of I K1 on the reentrant waves. Firstly, based on the TNNP06 model, the single pacing cell is derived by depressing I K1. And then, a 400 cells ×400 cells 2D tissue is developed by coupling the pacing cells together. Thirdly, the S1-S2 protocol is applied to inspire the reentrant waves. Next, the processes of the reentrant waves in the tissue corresponding to different I K1 are analysed. In addition, the action potentials of the cells in special locations are recorded and discussed. With the decrease of the I K1, the reentrant waves spin slowly and the period of reentrant waves increases. Meanwhile, the range of the action potential of the cells becomes larger when I K1 becomes smaller. The results suggest that with the decrease of I K1, the reentrant wave is weakened, and the systolic and diastolic functions of the tissue are enhanced at the same time.