Revealing reproductive efficacy and Hypercholesterolemia status in pregnant rats that treated with ginger

Abstract

Abstract Hypercholesterolemia is one of serious challenge during pregnancy that affects fetuses. This study has been undertaken to explore whether ginger supplementation maintains on delivery offspring in normal numbers and restore normal cholesterol levels in pregnant rats. Forty female rats with age 10 to 12 weeks have been divided into two groups; thirty Hpercholestrolemic pregnant rats and ten healthy pregnant rats. Hpercholestrolemic pregnant rats were equally divided into three groups; first group given normal saline, second group given simvastatin and third group treated with ginger after delivery litter size and weights were estimated for all dams. Dams were sacrificed and livers were removed and weighed, then fixed with 10% formalin and histopathological processing was performed. Results revealed that numbers of offspring in dams treated with ginger were nearby those of control while number of offspring from dams of simvastatin treated groups were significantly (P ≤ 0.05) decreased than those of control group. Histpoathological examination of liver rats of hyperchol+Simvastatin showed obvious dilatation of central hepatic vein and examination of liver in Simvastatin group showed dilatation of central hepatic vein. While histpoathological examination of liver rats of ginger group showed normal radiation of hepatocytes.