Association of irisin hormone with some physiological and inflammatory parameters of type 1 diabetic mellitus (TIDM) patiens in Thi-Qar province, Iraq

Abstract

Abstract The current study aimed to verify of irisin concentration in TIDM and the scan the association the irisin value with the physiological inflammatory parameters.The study included 60 individuals diagnosed in newly onset TIDM and 35 healthy individuals as acontrol group. IL-6 and C-reactive protein(CRP) concentration was calculated. Serum irisin level in addition to inflammatory factors were evaluated by ELISA kit.The results explained a sagnifecant increased at (P ≤ 0.05) in level of fasting blood sugar (FBS), HbA1C and irisin level in type I patients compared with the controlgroup, (7.95±2.024vs94±0.47mmol/dl, 6.91±1.094vs28±0.56mmol/dl, 33.38±7.ng/mlvs27.24±4.50ng/ml. respectively). So the results showed significantly decreased of BMI, C-peptide, Insulin and HOMO-IR level (p≤ 0.05) in GI contrast with control grouping (19.04±0.71 vs22.62±1.19, 0.21±0.02 vs 6.11±0.50, 0.19±0.04 vs 24.99±0.73, 0.06 ±0.02 vs5.49 ± 0.53 respectively). Investigation of lipid profile the results explained there was non-significant decreased of cholesterol (p≤ 0.05) in GI contrast with group’s control, but there was significant decreased of Tg, and HDL levels in GI contrast with group’s control, on the other hand the results showed a significant increase (p≤ 0.05) of LDL level in GI compared with control group(3.78±0.46vs3.96±0.46, 1.55±0.21 vs1.62±0.37, 1.02±0.15 vs1.52±0.37, 2.45±0.58 vs 2.11±0.45 respectively). The results of inflammatory parameters explained there was a significant increased (p≤ 0.05) of IL-6 and CRP levels in patients compared with control group (21.0±5.25vs12.79±0.93, 3.14±1.16 vs2.37±0.69 respectively) (Table 1). In TIDM grouped, iris in value showed negative association with (HbA1c) value (r=- 0.353, p<0.001), glucose (r=-0.290) and HOMO-IR(r=-0.232), cholesterol (r=-0.133), Tg, (r=-0.071-) and LDL(r=-0.163), So the correlation analysis explained a positive correlation with insulin level(r=0.055), C.peptide(r=0.105), HDL(r=0.229-), BMI(r=.115), IL-6(r=0.067), and CRP(r=0.171).