Synthesis of N-Mannich bases from 3, 4-dihydropyrimidin-2(1H)-ones by using nanostructured Cobalt Chloride Doped Polyaniline Composite as Catalyst (PANI-Co)

Abstract

Abstract The Mannich reaction is the type proton assisted of carbon-carbon bond formation reaction that involves the addition of resonance-stabilized carbon nucleophiles to iminium salts and imines. The product of the Mannich reaction is (3-amino carbonyl compounds of biological interest synthesized from the aldehyde, amine, and carbonyl compounds. This reaction is very limited to the only highly reactive aldehydes such as formaldehyde and acetaldehyde, a secondary amine. The direct Mannich-type reaction expanded with the development of the scope of Mannich reaction, and very much efficient method for highly stereo selective type Mannich reactions were extensively well studied and reported in the literature. This study aimed at investigating the synthesis of N-Mannich Bases from the 3, 4-Dihydropyrimidin-2(1H)-ones by using nanostructure Cobalt Chloride Doped Polyaniline composite as Catalyst (PANI-Co). The Synthesis of N-Mannich Bases from 3, 4-Dihydropyrimidin-2(1H)-ones by using nanostructure Cobalt Chloride Doped Polyaniline composite as Catalyst (PANI-Co) was carried out. The effective method for the synthesis of the Mannich bases of synthetically important compounds has been coined. We synthesized the different Mannich Bases from 3, 4-Dihydropyrimidin-2(1H)-ones which give up to 94 % yield.