Superparamagnetic nanopreparations in early diagnostics and treatment of cancer

Abstract

Abstract The superparamagnetic nanoparticles of magnetite citrate (SNMCs) consisting of nanospheres aggregates with the hydrodynamic diameter being between 15 to 35 nm with a magnetite core diameter of 3 to 12 nm, coated with of citrate anions was synthesized. A water 2-5% sol of SNMC was successfully tested as magnetic resonance imaging (MRI) contrast agent. The same 40% sol was then combined with Inox and used at regional magneto-thermo-chemo-therapy (RMTCT) of Lewis lung carcinoma (LLC) and Ehrlich carcinoma (EC), in female C57Bl / 6j mice. In the early stages of carcinoma development, the proliferation centers of LLC and EC cells were visualized and, during treatment, they obtained a significant increase in the efficiency of regional magneto-thermo-chemo-therapy.