A Novel Handheld Device: Application to in Situ Bioprinting Compound Dressing for the Treatment of Wound

Abstract

Abstract In recent years, Bioprinting technologies have been advancing at the convergence of automation, digitalization, and new tissue engineering (TE) approaches, In-situ bioprinting may be favored during certain situations for skin wound healing. The main advantage of in-situ printing is that the printed wound surface has good adhesion, namely the print of dressing can full fill the defect out of the wound, can adapt to different positions (joints) of the different types of wounds. In addition, the free deposition of materials and the properties of materials are well combined with the wound surface in the printing process, sticking to the wound surface and reducing the pain caused to the injured by the process. Handheld device to achieve in-situ printing, simplifies the surgical process, portable, easy to operate, can be used in emergency scenarios. Moreover, wound healing is a dynamic and complex process that contains several sequential phases. Rapid hemostasis and continuous bacteriostasis have always been problems in wound healing. Here, we firstly propose a hand-held device that combines multiple processes (spray, extrusion, electrospinning) and is oriented to accurate wound management. Secondly, we used this device to achieved the stable film formation of a variety of materials, and has the key functions of hemostasis, bacteriostasis and promoting healing. Finally, we highlight the potential of this device for wound healing applications.