Preparation and Characterization Biaryl aromatic compounds of the pyrimidine derivative by a Suzuki Coupling reaction and study their anti-cancer effect

Abstract

Abstract This study includes the synthesis and characterization of some heterocyclic compounds (pyrimidine derivatives) starting from the reaction of 2-Bromo benzaldehyde with the amino compound in an acidic medium to obtain a base derivative of Schiff Base (1) and then (1) interacts with aromatic boronic acids (3-Carboxyx-5-nitro, 3-Cyano, 4-Ethoxy, 2,3-Difluoro, 2,3,4-Trifluoro, 4-Chloro) respectively by reaction Suzuki-Mayura and with the presence of Tetrax (Triphenyl Phosphine) Palladium (0) and a basic medium to give new derivatives of Diphenyl (2-7). The derivatives that were manufactured were Characterization through the FT-IR spectroscopy, proton magnetic resonance spectrum 1H-NMR, and carbon carbon resonance spectrum 13C-NMR. In addition to the elemental analysis C.H.N, the cytotoxicity of the derivatives (2-4) was examined in the laboratory on a MCF-7 and SK-LU-1 using the MTT assay, and it was found that the derivative (2) had very good efficacy at a certain concentration.