Formulation and characterization of Pyrazinamide loaded pegylated polypropylene imine dendrimer and its alteration in the pharmacokinetics

Abstract

Abstract Current study aimed to build a dendrimer for tuberculosis treatment that was loaded with pyrazinamide. The medication pyrazinamide was loaded onto a PEGylated poly(propylene-imine) dendrimer. When it comes to tailored drug delivery, dendrimers are just plain awesome. Investigations into improving the drug loading capacity are being conducted on the free dendrimer, and the synthesised pyrazinamide loaded dendrimer. According to multiple studies, the core Ethylene Diamine (EDA)-PPI dendrimers of the ethylene diamine initiator can be effectively modified by PEGylation. This effort will increase therapeutic value and minimise changes in plasma concentration by carrying out drug transportation at a controlled rate. The therapeutic intervention for tuberculosis patients is enhanced by this feature. A pyrazinamide drug-loaded dendrimer was prepared in separate batches with varying concentrations; the optimal formulation was chosen and given to a rabbit, with the plasma concentration compared to that of the pure drug. Various pharmacokinetic parameters were calculated and the optimized formulation showed excel in the pharmacokinetic parameters.