The effect of high aluminium water consumption on parameters of neuron, blood and renal function

Abstract

Abstract Mining process causes contamination of Aluminium in drinking water consumed by Bangka Island residents. The study was conducted to identify the influence of high aluminium water consumption on serum aluminium level, serum brain derived neurotrophic factor (BDNF), serum ferritin, blood haemoglobin (Hb), and urine albumin to creatinine ratio (UACR). Men aged 26-45 years old were allocated into two groups. The first group was subjects who have consumed well water for at least 5 years. Aluminium levels in well water were sampled from seven wells and the average levels were higher than threshold. The control group was subjects who have consumed tap water for at least 5 years. The average level of aluminium in the tap water from seven houses was still within the normal limit. Serum aluminium levels of men who consumed high aluminium containing water were significantly higher than control group. Men who consumed high aluminium water had significantly lower levels of BDNF and ferritin, and were also associated with lower Hb levels. Both groups had no difference in UACR and were still within normal limits. High aluminium water consumption may have an impact to decrease the indicators of cognitive and blood functions, but has no effect on renal functions.