Formulation and evaluation of the cream made from potassium azeloyl diglycinate as an anti-aging

Abstract

Abstract Potassium Azeloyl Diglycinate has the ability to moisturize the skin, regenerate cells, increase skin elasticity, and hide fine lines. This research aims to discover the stability and effectiveness of anti-aging cream made from Potassium Azeloyl Diglycinate in regenerating and hydrating skin. The anti-aging cream formulation was made by varying the concentration of Potassium Azeloyl Diglycinate (0%,3%,5%,7%) and then the physical properties stability was evaluated. The best formula was going to be tested for its ability to regenerate the mouse’s skin cells that had erythema, and hydrated the respondent’s skin. In addition, an antioxidant activity was tested on pure Potassium Azeloyl Diglycinate and Vitamin C as the positive control. The results showed that the F2 Cream had the best physical properties stability evaluation results. The F2 Cream had the better ability to regenerate the mouse’s skin cells than the positive and negative control groups (the erythema diameter was 4.33 ± 4.04 mm), and was also able to increase the skin moisture of 12 respondents who participated in the research. The results of the antioxidant activity test showed that Potassium Azeloyl Diglycinate belonged to the very weak antioxidant group (IC50:83.946.587 ppm), while Vitamin C belonged to the very strong antioxidant group (IC50:1.684 ppm).