Growing human-scale scala tympani-like in vitro cell constructs

Author:

Aregueta Robles Ulises AORCID,Bartlett-Tomasetig Florence,Poole-Warren Laura A

Abstract

Abstract Emerging materials and electrode technologies have potential to revolutionise development of higher resolution next-generation, bionic devices. However, barriers associated with the extended timescales, regulatory constraints, and opportunity costs of preclinical and clinical studies, can inhibit such innovation. Development of in vitro models that mimic human tissues would provide an enabling platform to overcome many of these barriers in the product development pathway. This research aimed to develop human-scale tissue engineered cochlea models for high throughput evaluation of cochlear implants on the bench. Novel mould-casting techniques and stereolithography three-dimensional (3D) printing approaches to template hydrogels into spiral-shaped structures resembling the scala tympani were compared. While hydrogels are typically exploited to support 3D tissue-like structures, the challenge lies in developing irregular morphologies like the scala tympani, in which the cochlear electrodes are commonly implanted. This study successfully developed human-scale scala tympani-like hydrogel structures that support viable cell adhesion and can accommodate cochlear implants for future device testing.

Funder

Australian Government through the Australian Research Council’s Linkage Projects

Publisher

IOP Publishing

Subject

Biomedical Engineering,General Medicine,Biomaterials,Biochemistry,Bioengineering,Biotechnology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Sacrificial biomaterials in 3D fabrication of scaffolds for tissue engineering applications;Journal of Biomedical Materials Research Part B: Applied Biomaterials;2023-08-12

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