A fluorescence-T1MR dual-mode analysis method for Fe3+detection in serum

Abstract

Abstract Fe3+ is commonly found in living organisms and the surrounding environment, and an excessive amount of Fe3+ can cause significant harm to human health and the biological environment. Therefore, it is of great importance for human health to conduct a quantitative analysis of Fe3+. A dual-mode analytical method using MnO2/BSA/CdTe quantum dot complexes is developed for the detection of Fe3+ in solution. The variety of fluorescence intensity (F455 nm/F635 nm) of this system has an excellent linear relationship with the concentration of Fe3+ (0.7500–6.750 nmol·L−1) under the optimal conditions, and the lowest detection limit is 0.7004 nmol ·L−1. Meanwhile, the T1WI imaging performance of this system also shows a good linear relationship with concentraions of Fe3+ in a linear range of 0.7500–2.250 mmol·L−1, and the lowest detection limit of 0.2642 mmol·L−1. The quenching mechanism of this system is discussed, and results show that the interaction between Fe3+ and this system is a static quenching process. This fluorescence-T1MR dual-mode sensor is simple rapid, and easy operation, which could provide a new technology for detecting Fe3+ in solution.