Effective DBS treatment improves neural information transmission of patients with disorders of consciousness: an fNIRS study

Abstract

Abstract Objective. Deep brain stimulation (DBS) is a potential treatment that promotes the recovery of patients with disorders of consciousness (DOC). This study quantified the changes in consciousness and the neuromodulation effect of DBS on patients with DOC. Approach. Eleven patients were recruited for this study which consists of three conditions: ‘Pre’ (two days before DBS surgery), ‘Post-On’ (one month after surgery with stimulation), and ‘Post-Off’ (one month after surgery without stimulation). Functional near-infrared spectroscopy (fNIRS) was recorded from the frontal lobe, parietal lobe, and occipital lobe of patients during the experiment of auditory stimuli paradigm, in parallel with the coma recovery scale-revised (CRS-R) assessment. The brain hemodynamic states were defined and state transition acceleration was taken to quantify the information transmission strength of the brain network. Linear regression analysis was conducted between the changes in regional and global indicators and the changes in the CRS-R index. Main results. Significant correlation was observed between the changes in the global transition acceleration indicator and the changes in the CRS-R index (slope = 55.910, p < 0.001, R 2 = 0.732). For the regional indicators, similar correlations were found between the changes in the frontal lobe and parietal lobe indicators and the changes in the CRS-R index (slope = 46.612, p < 0.01, R 2 = 0.694; slope = 47.491, p < 0.01, R 2 = 0.676). Significance. Our study suggests that fNIRS-based brain hemodynamics transition analysis can signify the neuromodulation effect of DBS treatment on patients with DOC, and the transition acceleration indicator is a promising brain functional marker for DOC.