Laser analysis of the exhaled air isotope composition in diagnosing nosologically different H. pylori-associated diseases

Abstract

Abstract Laser spectroscopic analysis of the isotope composition of exhaled air was performed for diagnosing the digestive system diseases, associated with Helicobacter pylori infection. An analyzer of 13СО2/12СО2 ratio in exhaled air based on tunable diode lasers and 13С-urea breath test (13С-UBT) were used to diagnose the infection. Nosologically different gastro-intestinal tract diseases: gastric and duodenal ulcer, gastritis and duodenitis were studied. The data of morphologic analysis of the gastric and duodenal mucosa, obtained during fibreoptic gastroduodenoscopyfor 612 patientshave been compared with the results of isotope breath test. The dependence has been analysed of laser 13С-UBT results on nosology and localisation of the H. pylori colony.