Abstract
Abstract
The present paper aimed to detect the effects of rifampicin on the enzymatic activity of some liver enzymes (GPT, GOT, ALP). 40 adult male rats were used in this study, randomly divided into four equal groups for each drug, control group and three groups administrated GOTric dose - Low, medium and high (50, 100, 150 mg/kg) for a period of 28 days, and the rat’s weights averaged from 225 - 260 g at the age of 5 months, after which blood was drawn from animals for the purpose of obtaining the serum for the required functional tests, which is to measure the level of liver enzymes GPT, GOT. ALP. The results of the current study recorded a significant increase (P <0.05) in the level of enzymes (GPT, GOT, ALP) in groups of rats treated with rifampicin drug compared with the control group.