Kelubi Fruit (Eleiodoxa conferta) extract as a Green Catalyst Synthesis of 3,4-dihydropyrimidin-2 (1H)-ones

Abstract

Abstract The use of synthetic strong acid catalysts or lewis acid catalysts from metals often causes environmental problems at the end of a chemical reaction. In this research offers an alternative solution using kelubi fruit extract (Eleiodoxa conferta) as a green catalyst, especially in the synthesis of 3,4-dihydropyrimidin-2 (1H)-ones derivatives which are reported to be active as therapeutic and bioorganic chemistry. So the purpose of this research was to develop a green catalyst from natural fruit for the synthesis of 3,4-dihydropyrimidin-2 (1H)-ones using kelubi fruit. The Green catalysts are obtained from water extracts of kelubi fruit that are ripe. Then the catalyst is added to the reagent for the synthesis of pyrimidine derivatives that consist of urea, benzaldehyde, and ethyl acetoacetate (equivalent). As a comparison, HCl is used as an acid catalyst. The result is the highest yield (67,7%) at the use of 0,2 ml green catalyst and reaction time 180 minutes. Spectrum UV-Vis of characteristics compound has a maximum wavelength of 306 nm.