The Correlation between Serum Tryptase Level and Ventricular Remodeling in Patient with Acute Coronary Syndrome After 1 Month of Onset

Abstract

Abstract Tryptase, an enzyme secreted by mast cell, is suggested to play a significant role in the pathophysiology of acute coronary syndrome (ACS) and subsequent ventricular remodeling (VR). This study aimed to understand the correlation between the serum level of tryptase and VR in patients with ACS after one month of onset. Sampling method was total sampling where patients with ACS enrolled in the study were allocated into two groups based on their serum tryptase level, lower level (n=13) and higher level (n=12) groups. All subjects underwent echocardiography examination on admission to obtain their initial data and they were reevaluated one month later for the signs of VR. The occurrences of VR were examined by echocardiography with LVEDP and LVESV used as the VR parameters. Fisher Exact Test showed no significant difference between both groups in term of VR (p=0.668). The contingency coefficient analysis revealed no correlation between tryptase level and the occurrence of VR (p=0.113). However, the multiple regression analysis suggested that LVEDP and LVESV demonstrated multicollinearity to tryptase and VR. Although the current study concluded no correlation between tryptase level and VR following ACS, a prospective study with longer follow-up time is expected to gain more information.