Effect of Alcoholic Extract of Carrichtera annua Plant on the Growth of Leishmania donovani Parasite, In vitro Study

Abstract

Abstract The current study was conducted to find out the efficacy of the alcohol extract of Al-Khashin plant Carrichtera annua plant in treating the Leishmania donovani parasite In vitro, where the concentration of 1.5 mg/ml resulted in an inhibitory effect on the growth of the promastigote of parasites at a percentage of 50% (LCD50) during 96 an hour at a rate of 38.1 x 103 cells/cm3 compared to the control treatment 76.2 x 103 cells/cm3, the results showed the significant inhibitory effect of the alcohol extract of Al-Khashin plant on the growth of Leishmania parasites, which led to a decrease in the number of generations and an increase in their time, as the number of generations reached 108.7 generation compared to the control treatment reached 232.5 generations using the same concentration within 96 hours of treatment, an inverse relationship was observed between increased concentration and generation time. The conclusion of the present study is the high efficiency of C. annua alcoholic extract in treating the L. donovani parasites as it led to an apparent inhibition of the growth of promastigote that was treated with different concentrations of the alcoholic extract of the plant.