Changes in lipid profiles of hypercholesterolemic rat (Rattus norvegicus) treated with iles-iles synbiotic effervescent tablets

Abstract

Abstract The development of innovations in the use of functional food is growing, especially in the health sector. Synbiotic products are developed by combining prebiotics with probiotics. Synbiotic effervescent tablets provide prebiotic and probiotic compounds as supplements so they can be consumed and provide healthy effects. This study aims to determine the effect of giving synbiotic effervescent tablets from iles-iles tubers on lipid profiles and determine the lowest dose of synbiotic effervescent tablets in reducing cholesterol levels in blood rats. This study used the Randomized Complete Block Design as the experimental design, with a dose of tablet treatment 0.045 g/day/200 g rat body weight (half of normal dose), 0.09 g/day/200 g rat body weight (normal dose), and 0.18 g/day/200 g rat body weight (twice of normal dose). Rats given distilled water without being treated with tablets were used as controls. The lipid profiles (total cholesterol, triglycerides, HDL, and LDL) of the rats were measured after the treatment. Body weight changes were also monitored throughout the study. Treatment using synbiotic effervescent tablets at all doses for 28 days can lower total cholesterol, triglycerides, and LDL and increase HDL. The highest cholesterol reduction (49.94%) was found in rats given tablet doses twice the normal dose for 28 days.