Abstract
Abstract
Begonia medicinalis or known as benalu batu in Indonesia is a herbal plant that is locally used for traditional medicines. The secondary metabolites such as flavonoids, alkaloids, steroids, and terpenoids have been reported to be found in these plant extracts. The content of flavonoids can lead to anti-cancer abilities while heat-sensitive flavonoid compounds can be extracted by the Ultrasound-assisted Extraction (UAE) method. In this study, the anticancer potential of B. medicinalis extracts from the leaves (leaves extract/LE) and stem (stem extract/SE) in three cell lines (Hela, MDA-MB, HT-29) have been performed. Extraction of the leaves and stems was carried out using water as a solvent and the ultrasound-assisted extraction (UAE) method followed by measuring the total flavonoid content (TFC) of each extract. The anticancer potential was obtained from cytotoxic measurements by the MTT method on 3 types of cancer cells incubated with the extract for 24 hours. The value of total flavonoid content (TFC) in the LE was higher than that of SE extracts. Both extracts have the potential as a remedy for the treatment of cancer. Keywords: Begonia medicinalis, Ultrasound-assisted Extraction (UAE), anticancer
Reference41 articles.
1. Flavonoids in the leaves of Hillebrandia and Begonia species (Begoniaceae);Iwashina;Biochemical Systematics and Ecology,2020
2. Review on ethnomedicinal, phytochemical and pharmacological evidence of Himalayan anticancer plants;Tariq;Journal of Ethnopharmacology,2015
3. An ethnobotanical survey of wild edible plants used by the Yi people of Liangshan Prefecture, Sichuan Province, China;Wang;Journal of Ethnobiology and Ethnomedicine,2020
4. THE USE OF VARIOUS PLANT TYPES AS MEDICINES BY LOCAL COMMUNITY IN THE ENCLAVE OF THE LORE-LINDU;Gailea;Global Journal of Research on Medicinal Plants & Indigenous Medicine || GJRMI ||,2016