Hypoglycemic and lipid-lowering effects of extracted from the aerial part of Urtica cannabina L. on alloxan-induced hypergl-ycemic mice

Abstract

Abstract To evaluate the potential effect of Urtica cannabina L. (UC)in type 1 diabetes, we herein investigated the hypoglycemic and hypolipidemic effects and the underlying mechanism of ethanol extracted from the aerial part (AUC)and underground part of Urtica cannabina L(UUC) using alloxan-induced hyperglycemic mice model. The aerial part and underground part of Urtica cannabina L was extracted with 95% ethanol was administered orally (AUC and UUC: at 500, 1600mg/kg body weight) every day for 1 weeks to investigate the anti-diabetic effects in alloxan-induced mices. blood glucose and body weight of the mice were recorded daily, and serum levels of total cholesterol, triglycerides and glycosylated hemoglobin were measured. Compared with thediabetic mice, treatment group affected the weight loss of diabetic mice to different degrees and reduced the blood glucose level. The crude extract of Urtica cannabina L also normalizes lipid metabolism parameters. Compared with the diabetic control group, the administration of the high-dose urticaria high-dose group significantly (P <0.05) reduced the levels of serum triglycerides (P <0.05) and cholesterol (P <0.05). This study suggests that in the mouse model of hyperglycemia caused by diabetic alloxan, Urtica cannabina L has significant hypoglycemic and hypolipidemic activity, these provided scientific basis for the high-value utilization of Urtica cannabina L and healthy consumption.