Lipid Metabolism in Urban Residents with Type 2 Diabetes and Cardiovascular Diseases

Abstract

Abstract The paper studies the lipid and lipoprotein spectrum in blood serum from Barnaul residents suffering from type 2 diabetes mellitus (type 2 diabetes) and cardiovascular diseases (CVD). The authors examined 187 people (98 women and 89 men) with type 2 diabetes and CVD, aged 30-90. All subjects in the blood serum were tested for total cholesterol (TC), cholesterol of low-density lipoprotein (LDLC), very low-density lipoprotein cholesterol (VLDLC), high-density lipoprotein cholesterol (HDLC), and triglycerides (TG). The TC, LDLCl, VLDLC, HDLCl, and TG concentration were established on the Konelab automatic analyzer (manufactured by “Thermo Fisher Scientific Oy,” Finland). In the lipid spectrum of blood in women with CVD, the level of TC is above the reference values. A similar situation is observed with TG in the blood in patients with verified diabetes type 2 and CVD. The concentration of LDL cholesterol in the blood of women with cardiovascular pathologies exceeds the norm. The level of HDL cholesterol in men with type 2 diabetes, on the contrary, is below the reference values. There are significant differences in HDL cholesterol content in the blood between men and women with type 2 diabetes and cardiovascular diseases. Additionally, a significant difference in the level of TC and LDL-C is established in residents with both pathologies. Lipidogram indices are of prognostic value in CVD development in patients with type 2 diabetes and with cardiovascular pathologies.