Prenatal and postnatal correction of the immunobiological status of calves with a drug based on cyclic nucleotides

Abstract

Abstract The resistance of young cattle to diseases is formed during intrauterine development. Oral administration of a drug that is made from the spleen of cattle and contains nucleosides and nucleopeptides at a dose of 0.1 g/kg of live weight to mother cows once within 5 days before calving increased the triglyceride level in the blood serum of newborn calves by 17.6-35.3%, calcium by 8.9-10.3%, magnesium by 2.3-1.5%, globulins by 8.54-9.45%, sum of immunoglobulins, percentage and absolute concentration of immunoglobulins A and G. The drug neutralised the negative effects of vaccination of cows and calves on the calves’ liver. The introduction of this drug to calves within 5 days after birth in the same dose as to cows stimulated the protein-synthetic function of the liver, an increase in total protein due to the globulin fraction, the total concentration of serum immunoglobulins by more than 2% and the absolute and percentage content of immunoglobulins A and M. The drug contributed to an increase in glucose by 12.8%, triglycerides by 8.7%, magnesium by 12.6%, calcium by 11.2%, stimulated structure-forming functions, transmembrane transport due to phosphorylation of enzymes and structural proteins. Thus, the supplement based on nucleosides and nucleopeptides controlled the course of various physiological processes, metabolism, membrane transport mainly associated with the exchange of Ca and Mg. The results obtained provide grounds to recommend the drug for the correction of the immunobiological status of calves in the prenatal and postnatal development periods.