Author:
Nurilmala M,Irawan M F,Wientarsih I,Pranata A W,Putri E A W
Abstract
Abstract
Gelatin is produced from animal skin and bones, which can be used as an ingredient in medicine capsules. There are issues regarding the mad cow disease and certain religious rules that do not allow the consumption of gelatin from pigs and cows, opening up opportunities for developing gelatin derived from fish. This study aims to determine the level of toxicity of pangasius skin gelatin capsules (Pangasius sp.) using the fixed-dose procedure method in mice based on the LD50 value. The 2,000 mg/kg BW dose is determined as the initial dose of the main test after the preliminary test. The test animals were divided into 2 groups, each containing 5 female mice of the DDY strain. The first group was the control group, and the second group was the test animal group which was treated with a dose of 2,000 mg/kg BW. The results showed that the LD50 value of pangasius skin gelatin was > 2,000 mg/kg BW. Pangasius skin gelatin is not toxic, as evidenced by the absence of death and changes in the average body weight of mice. Based on the significant difference in relative weight, only the lungs were affected by pangasius skin gelatin.