Prediction of secondary, tertiary protein structure and interaction eIF4E from Capsicum annum with Rep Geminivirus

Abstract

Abstract The eIF4E gene is a gene that plays a role in the initiation of protein translation. This gene is relatively conserved and is present in all organisms. In humans, this gene functions as a proto-oncogene, its expression and activation are associated with transformation and tumorigenesis. The eIF4E protein takes a role in the translation initiation by recruiting ribosomes to the 5’-cap structure. In some conditions, it functions as an initiator in the process of translation and co-factor of the plant’s defense system from virus attacks. The eIF4E protein also can bind with the genome linked viral protein to turnip mosaic virus [TuMV] in Capsicum annum. Their interaction is effective for virus infectivity and upregulated genome amplification. Understanding the tertiary structure of the eIF4E protein and its ligands will help in elucidating its interactions with viruses. So that it can be used to avoid spreading the virus in chili plants.