Study of the Effect of Laboratory-Made Functional Pasta on some Biochemical Characteristics in Male Rats Suffering from Hyperglycemia

Abstract

Abstract This study was conducted in the laboratories of the Department of Food Sciences - College of Agriculture – University of Tikrit. The animal house of the College of Veterinary Medicine, with standard number 1601A301C011, University of Tikrit, was used for the period from 5/1/2022 to 6/1/2022. The experiment aimed to manufacture functional pasta with a 40% replacement rate Of oat flour, fortified with some medicinal plants, and a demonstration of some of its physiological effects in male rats suffering from alloxan-induced hyperglycemia, as the results of the biological experiment, for a period of 30 days, showed a significant increase in the weights of rats with H fenugreek, Z ginger, D cinnamon, and HZD, a mixture of equal proportions of fenugreek and ginger. For the two students, the highest weight gain was in the HZD mixture, which amounted to -0.32 mg/kg compared to the C2 infected control, which amounted to -25.33 mg/kg. The effect of the study on CBC parameters, the results of white blood cells (WBC) showed a significant decrease in D, reaching 9.20 cells3/mm106 when compared with the infected control, which amounted to 9.58 cells3/mm106. As for red blood cells (RBC), they decreased significantly in Z compared to C1. The results also showed a significant decrease in blood hemoglobin Hb, which reached 10.00 g/dL compared to C1, which amounted to 10.60 g/dL. As for platelets, PLT, they increased significantly in H D Z when compared with C1. As for its effect on lipid profile, the results showed a significant decrease. Cholesterol in the HZD treatment reached 83.66 mg/dL compared to C1, which was 92.33 mg/dL. The results showed that for triglycerides, there was a significant decrease in HZD, which was 67.66 mg/dL compared to C1, which was 75.66 mg/dL. As for high-density lipoprotein (HDL), it increased significantly in Z compared to C1, while low-density lipoprotein (LDL) increased in C1 and decreased. In D, as for the effects of different treatments on the glucose index, the results showed a significant decrease in Z and D, which were 184.00 and 187.50 mg/dL, respectively, compared to C1, which amounted to 237 mg/dL. As for VLDL, it decreased significantly in HDZ compared to C+, which amounted to 15.13 mg/dL.