Prospects of Wasteless Technologies of Selective Alcohols Oxidation

Abstract

Abstract The effect of aliphatic and heterocyclic amines on the selective oxidation reaction of alcohols by the catalytic system 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-acetylamino-TEMPO) - iodine was researched. Diethylamine, triethylamine, piperidine, 2,2,6,6-tetramethylpiperidine (pKa 11.01-11.12 ) and pyridine, 4-acetylpyridine, quinoline, isoquinoline ( pKa 4.8-5.4) were used for research. An almost waste-free method was developed for preparation esters from aliphatic alcohols by oxidizing in a two-phase medium CH2Cl2 - an aqueous solution of NaHCO3 by a two-mediator 4-acetylamino-2,2,6,6-tetramethylpiperidin-1-oxyl - iodine catalytic system, which allows selective oxidation alcohols in one stage. The results of the study may find application in the chemical, pharmaceutical and agrochemical industry, since the developed method is environmentally and economically beneficial, and the oxidation of alcohols in order to obtain various carbonyl and carboxyl compounds in these industries is one of the priority areas.