Study on the Synthesis of Charge Transfer Complex of Nifedipine and Tetracyanoethylene

Abstract

Abstract Purposes: To construct a new method for the determination of nifedipine and apply it to the determination of in vitro drugs in order to achieve simple and accurate quantitative detection. Procedures: A charge transfer complex of nifedipine tetracyanoethylene was constructed, and the fluorescence intensity changes of the complex and nifedipine were compared. Screen the effect of drug dosage, reaction time and reaction temperature on the fluorescence intensity of the system. Results: Nifedipine is a substance with its own fluorescence characteristics, but its own fluorescence intensity is not as high as expected. Through the addition of tetracyanoethylene, it is found that the fluorescence intensity of nifedipine has been greatly enhanced, combined with ultraviolet A new absorption peak was found in the spectrum, indicating that the two were successfully complexed. Conclusions: The experiment successfully synthesized the nifedipine charge transfer complex, and constructed a new method for the determination of nifedipine content, which is of great significance for the determination of the content of drugs in vitro.