The effect of antioxidants on the microstructure of tissues in the experimental aseptic inflammation focus

Abstract

Abstract The results of studying the intramuscular administration effect of ethyl methylhydroxypyridine succinate are presented in the article, as well as administration of the Flunidzhekt drug and the new Antioxidant anti-inflammatory drug for animals on the course of aseptic inflammation in white laboratory mice. After provoking the inflammation by subcutaneous turpentine oil injection, experimental animals were administered intramuscularly with abovementioned pharmaceutical substances for five days. Abscessing soft tissues of white mice obtained from an inflammatory lesion were subjected to microscopic examination. Microscopy of substances obtained from animals of the control group, in which no therapeutic agents were used, established that the pathological process proceeded against the background of significant leukocyte infiltration of the affected areas. In contrast, development signs of regenerative processes were observed on microsections made from the tissues of mice that were injected with ethylmethylhydroxypyridine succinate. The onset of those signs was predicted by the increase in the proliferation of fibroblasts with a decrease in leukocyte infiltration. After using the “Flunidzhekt” drug, it was noted to be highly effective in suppressing the intensity of the inflammatory process. But it was also noted that the most optimal microscopic picture was observed in pathological tissues obtained from animals that used the Antioxidant anti-inflammatory drug for animals. The use of ethyl methylhydroxypyridine succinate has a positive effect on the course of the inflammatory process, helping to reduce pathological changes in tissues in the outbreak and accelerating the healing process. Moreover, the use of the Antioxidant anti-inflammatory drug for animals helps accelerate the regeneration of the outbreak and reduces the severity of its pathogenetic effects.